{"id":65,"date":"2014-09-21T15:38:46","date_gmt":"2014-09-21T15:38:46","guid":{"rendered":"http:\/\/behavioralhealthmn.com\/blog\/?p=65"},"modified":"2021-11-22T14:58:01","modified_gmt":"2021-11-22T20:58:01","slug":"blood-tests-can-id-depression-predict-best-therapy-approach","status":"publish","type":"post","link":"https:\/\/www.behavioralhealthmn.com\/blog\/2014\/09\/21\/blood-tests-can-id-depression-predict-best-therapy-approach\/","title":{"rendered":"Blood Tests Can ID Depression, Predict Best Therapy Approach"},"content":{"rendered":"

We wanted to share this was a very interesting article written by Rick Nauert, PHD, Senior News Editor at Psych Central\u00ae about how blood test can help identify depression and in turn, the best therapy approach for helping the individual. Please contact Healthwise Behavioral Health<\/a> for more information.<\/p>\n

Blood Tests Can ID Depression, Predict Best Therapy Approaches<\/h3>\n

By\u00a0RICK NAUERT PHD<\/a>\u00a0Senior News Editor<\/em>
\nReviewed by John M. Grohol, Psy.D. on September 18, 2014<\/p>\n

For years, researchers have been trying to find a reliable \u201cbiomarker\u201d for diagnosing\u00a0depression<\/a>.<\/p>\n

That quest may now be a reality, with\u00a0the development of a blood test that provides the first objective, scientific diagnosis for depression \u2014 and who may benefit from a widely used form of\u00a0psychotherapy<\/a>\u00a0for it.<\/p>\n

Northwestern Medicine\u00ae scientists report the test identifies depression by measuring the levels of nine RNA blood markers. RNA molecules are the messengers that interpret the DNA genetic code and carry out its instructions.<\/p>\n

The blood test also predicts who will benefit from cognitive-behavioral therapy based on the behavior of some of the markers. Experts believe this knowledge will provide the opportunity for more effective, individualized therapy for people with depression.<\/p>\n

In addition, the test showed the biological effects of cognitive-behavioral therapy, the first measurable, blood-based evidence of the therapy\u2019s success. The levels of markers changed in patients who had the therapy for 18 weeks and were no longer depressed.<\/p>\n

\u201cThis clearly indicates that you can have a blood-based laboratory test for depression, providing a scientific diagnosis in the same way someone is diagnosed with high blood pressure or high cholesterol,\u201d said Eva Redei, Ph.D., a professor of psychiatry and behavioral sciences at Northwestern University Feinberg School of Medicine.<\/p>\n

\u201cThis test brings mental health diagnosis into the 21st century and offers the first personalized medicine approach to people suffering from depression.\u201d<\/p>\n

Redei is co-lead author of the study published in the journalTranslational Psychiatry<\/em>.<\/p>\n

Redei previously developed a blood test that diagnosed depression in adolescents. Most of the markers she identified in the adult depression panel are different from those in depressed adolescents.<\/p>\n

Experts acknowledge that the search for a biological diagnostic test for major depression has been ongoing for decades.<\/p>\n

Currently, diagnosing depression is subjective and based on non-specific symptoms such as poor mood, fatigue, and change in appetite, all of which can apply to a large number of mental or physical problems.<\/p>\n

A diagnosis also relies on the patient\u2019s ability to report his symptoms and the physician\u2019s ability to interpret them. But depressed patients frequently underreport or inadequately describe their symptoms.<\/p>\n

\u201cMental health has been where medicine was 100 years ago when physicians diagnosed illnesses or disorders based on symptoms,\u201d said co-lead author David Mohr, Ph.D., a professor of preventive medicine.<\/p>\n

\u201cThis study brings us much closer to having laboratory tests that can be used in diagnosis and treatment selection.\u201d<\/p>\n

The new blood test will allow physicians for the first time to use lab tests to determine what treatments will be most useful for individual patients.<\/p>\n

\u201cCurrently we know drug therapy is effective but not for everybody and psychotherapy is effective but not for everybody, \u201d Mohr said.<\/p>\n

\u201cWe know combined therapies are more effective than either alone but maybe by combining therapies we are using a scattershot approach. Having a blood test would allow us to better target treatment to individuals.\u201d<\/p>\n

Major depressive disorder affects 6.7 percent of the U.S. adult population in a year, a number that is rising. There is a two-to 40- month delay in diagnosis, and the longer the delay, the more difficult it is to treat depression.<\/p>\n

An estimated 12.5 percent of patients in primary care have major depression but only about half of those cases are diagnosed. A biologically based test has the potential to provide a more timely and accurate diagnosis.<\/p>\n

The current study included 32 patients, ages 21 to 79, who had been independently diagnosed as depressed in a clinical interview, and 32 non-depressed controls in the same age range.<\/p>\n

Some of the patients had been on long-term\u00a0antidepressants<\/a>\u00a0but were still depressed. The patients, from Northwestern general internal medicine clinics, also were participating in a previously reported study comparing the effectiveness of face-to-face and telephone-administered\u00a0cognitive behavioral\u00a0therapy.<\/p>\n

At baseline before the therapy, Northwestern scientists found nine RNA blood markers with levels significantly different in the depressed patients from those of controls. These markers were able to diagnose depression.<\/p>\n

After 18 weeks of therapy (face-to-face and telephone), the changed levels of certain markers could differentiate patients who had responded positively and were no longer depressed (based on a clinical interview and patients\u2019 self-reported symptoms) from patients who remained depressed.<\/p>\n

This is the first biological indicator of the success of cognitive behavioral therapy, the study authors said.<\/p>\n

In addition, the blood test predicts who will benefit from the cognitive behavioral therapy based on a distinct pattern or fingerprint of the levels of the nine marker levels at baseline in patients who recover from depression as a result of the therapy.<\/p>\n

\u201cThis distinction could be used in the future to predict who would respond to the therapy,\u201d Redei said.<\/p>\n

Researchers discovered the blood concentration of three of the nine RNA markers remained different in depressed patients and non-depressed controls, even if the depressed patients achieved remission from depression after the therapy.<\/p>\n

This appears to indicate a vulnerability to depression.<\/p>\n

\u201cThese three markers move us towards the ultimate goal of identifying predisposition to depression, even in the absence of a current depressive episode,\u201d said Redei.<\/p>\n

\u201cBeing aware of people who are more susceptible to recurring depression allows us to monitor them more closely,\u201d Mohr noted.<\/p>\n

\u201cThey can consider a maintenance dose of antidepressants or continued psychotherapy to diminish the severity of a future episode or prolong the intervals between episodes.\u201d<\/p>\n

Source:\u00a0Northwestern University<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

We wanted to share this was a very interesting article written by Rick Nauert, PHD, Senior News Editor at Psych Central\u00ae about how blood test can help identify depression and…<\/p>\n","protected":false},"author":3,"featured_media":497,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2,5],"tags":[119,38,32,37],"_links":{"self":[{"href":"https:\/\/www.behavioralhealthmn.com\/blog\/wp-json\/wp\/v2\/posts\/65"}],"collection":[{"href":"https:\/\/www.behavioralhealthmn.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.behavioralhealthmn.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.behavioralhealthmn.com\/blog\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/www.behavioralhealthmn.com\/blog\/wp-json\/wp\/v2\/comments?post=65"}],"version-history":[{"count":1,"href":"https:\/\/www.behavioralhealthmn.com\/blog\/wp-json\/wp\/v2\/posts\/65\/revisions"}],"predecessor-version":[{"id":445,"href":"https:\/\/www.behavioralhealthmn.com\/blog\/wp-json\/wp\/v2\/posts\/65\/revisions\/445"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.behavioralhealthmn.com\/blog\/wp-json\/wp\/v2\/media\/497"}],"wp:attachment":[{"href":"https:\/\/www.behavioralhealthmn.com\/blog\/wp-json\/wp\/v2\/media?parent=65"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.behavioralhealthmn.com\/blog\/wp-json\/wp\/v2\/categories?post=65"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.behavioralhealthmn.com\/blog\/wp-json\/wp\/v2\/tags?post=65"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}